- 询价
- 重组小鼠 gp130 / IL6ST / CD130 蛋白
- 湖北武汉
- 2025年07月16日
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强耀生物
| 规格 | 20ug |
| 编号 | CZDB-001 |
| 分子别称 | Ac1055, Gp130, Il-6rb |
| 分子种属 | Mouse |
| 表达标签 | His，S |
| 表达宿主 | E. coli |
| 浓度 | > 95 % as determined by SDS-PAGE |
| 缓冲液 | Lyophilized from sterile PBS, pH 7.4 |
| 存储条件 | -70°C，应避免反复冻融。 |
| 基本描述 | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
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Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130
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