- ￥960 - 1600
- Solarbio
- 北京
- K110727P-100ul
- 2025年07月11日
- IHC
- Rabbit
- Human ; Mouse
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- 详细信息
- 技术资料
- 免疫原：
Recombinant protein of human BBS5
- 亚型：
IgG
- 形态：
液体/冻干粉
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
多克隆
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，SAlexa Fluor 350，SAlexa Fluor 405，SAlexa Fluor 488，SAlexa Fluor 532，SAlexa Fluor 555，SAlexa Fluor 568，SAlexa Fluor 594，SAlexa Fluor 633，SAlexa Fluor 640，SAlexa Fluor 647，SAlexa Fluor 660，SAlexa Fluor 680，SAlexa Fluor 750
- 适应物种：
Human ; Mouse
- 保质期：
1-3年
- 抗原来源：
Recombinant protein of human BBS5
- 目录编号：
129880
- 级别：
科研级别
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:50-200.
- 靶点：
BBS5
- 抗体英文名：
Anti-BBS5 Polyclonal Antibody
- 抗体名：
巴尔得-别德尔综合征相关蛋白5抗体
- 规格：
100ul/50ul
| 规格： | 100ul | 产品价格： | ￥1600.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥960.0 |
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
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