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文献和实验Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity
This chapter describes methods utilized in establishing a mouse model of neuropsychiatric lupus encompassing both cognitive and emotional dysfunction, and a model of the influence of maternal antibody on the developing brain. The antibody
Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier
Besides its important role in folate homeostasis, membrane transport is a critical determinant of the antitumor activities of anti folate therapeutics used in cancer chemotherapy, such as methotrexate (MTX) and an exciting new generation
The use of oligodeoxynucleotides (ODN) to disrupt gene function has been studied in a variety of in vitro and in vivo systems (1 –14 ). Antigene, antisense, ribozyme, and aptamer nucleic acid molecules have been shown in numerous model
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