别 名:APJ receptor; AGTR L1; AGTRL 1; AGTRL1; Angiotensin II receptor like 1; Angiotensin receptor like 1; Apelin receptor; APJ; B78; FLJ90771; G protein coupled receptor APJ; GPCR34; HG 11; HG11; MGC45246; MSR; msr/apj; Aplnr; Agtrl1; APLNR; FLJ96609; APJ_HUMAN.
货号:YLK-KT0569
分 子 量:42kDa
细胞定位:细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码 G 蛋白偶联受体基因家族的成员。 编码的蛋白质与血管紧张素受体有关,但实际上是一种抑制腺苷酸环化酶活性的apelin受体,通过发挥高血压作用,对血管紧张素II的压力作用起反调节作用。 它在心血管和中枢神经系统、葡萄糖代谢、胚胎和肿瘤血管生成中以及作为人类免疫缺陷病毒 (HIV-1) 辅助受体发挥作用。 已鉴定出由可变剪接产生的两种转录变体。
Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Subcellular Location: Cell membrane.
Tissue Specificity: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.