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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名:
Gemtuzumab Ozogamicin
- 靶点:
CD33[Homo sapiens]
- 浓度:
1mg/ml
- 宿主:
CHO cells
- 保质期:
12个月
- 级别:
科研
- 供应商:
武汉天德生物科技有限公司
- 保存条件:
store at -80°C
- 亚型:
IgG4-kappa
- 规格:
1mg
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文献和实验AntibodyCytotoxic Agent Conjugates: Preparation and Characterization
cytotoxic agents that inhibit essential cellular targets such as microtubules or DNA. Antibody–cytotoxic agent conjugates (ACCs) against several types of cancer are currently in advanced stages of clinical trials and one, gemtuzumab ozogamicin (Mylotarg�
【翻译】Development trends for monoclonal antibody cancer therapeutics
%) were drug–mAb conjugates, although an equal number of drug and protein immunoconjugates (6 candidates each) are now in the clinic. Only one immunotoxin, gemtuzumab ozogamicin (Mylotarg; UCB/Wyeth), a humanized mAb conjugated to calicheamicin
瘤和白血病等。Mylotarg是由抗CD33分子的单抗和抗肿瘤抗生素calicheamicin连接的偶联物,在抗肿瘤单抗药物中,是第1个于2000年获批准上市的药物与单抗偶联物de Vetten[12]等用抗CD33-Calicheamicin偶合剂(gemtuzumab ozogamicin, CMA-676)治疗1例Ph’染色体阳性AML,用CMA-676单独用药2次,即获细胞形态学和细胞遗传学水平的CR,用实时PCR的方法检查,发现该制剂可杀灭骨髓内3个log的肿瘤细胞。。2、放射免疫偶联物将放射性核素连接在单抗
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