MDCK/MDCK/MDCK/犬肾上皮细胞

MDCK/MDCK细胞系/MDCK细胞株/MDCK犬肾上皮细胞

Cell line name MDCK

Synonyms MDCK (NBL-2); MDCK(NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney

Accession CVCL_0422

Resource Identification Initiative To cite this cell line use: MDCK (RRID:CVCL_0422)

Comments Group: Vaccine production cell line.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Characteristics: Used for virus production for vaccine development, toxicology and industrial biotechnology research, and high-throughput screening (ATCC=CCL-34).

Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).

Omics: Transcriptome analysis by RNAseq.

Caution: There seem to be two distinct cell lines which were assigned NCBI_Iran catalog number C426.

Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Cell type: Epithelial cell of kidney; CL=CL_0002518.

Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)

Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.

Hierarchy Children:

Age at sampling Adult

Category Spontaneously immortalized cell line

PubMed=13901412; DOI=10.1126/science.138.3536.42

Green I.J.

Serial propagation of influenza B (Lee) virus in a transmissible line of canine kidney cells.

Science 138:42-43(1962)

 

PubMed=5918973; DOI=10.3181/00379727-122-31293

Gaush C.R., Hard W.L., Smith T.F.

Characterization of an established line of canine kidney cells (MDCK).

Proc. Soc. Exp. Biol. Med. 122:931-935(1966)

 

DOI=10.1007/BF02618370

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.

The animal cell culture collection.

In Vitro 5:1-16(1970)

 

PubMed=222773; DOI=10.1083/jcb.81.3.635; PMCID=PMC2110404

Rindler M.J., Chuman L.M., Shaffer L., Saier M.H. Jr.

Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK).

J. Cell Biol. 81:635-648(1979)

 

PubMed=6480288

Schroyens W., Bruyneel R., Tchao R., Leighton J., Dragonetti C.H., Mareel M.M.

Comparison of invasiveness and non-invasiveness of two epithelial cell lines in vitro.

Invasion Metastasis 4:160-170(1984)

 

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Romanova J., Katinger D., Ferko B., Voglauer R., Mochalova L., Bovin N., Lim W., Katinger H., Egorov A.

Distinct host range of influenza H3N2 virus isolates in Vero and MDCK cells is determined by cell specific glycosylation pattern.

Virology 307:90-97(2003)

 

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022

Karger A., Bettin B., Lenk M., Mettenleiter T.C.

Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.

J. Virol. Methods 164:116-121(2010)

 

PubMed=21819694; PMCID=PMC3123757

Omeir R.L., Teferedegne B., Foseh G.S., Beren J.J., Snoy P.J., Brinster L.R., Cook J.L., Peden K., Lewis A.M. Jr.

Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby canine kidney cells.

Comp. Med. 61:243-250(2011)

 

PubMed=21982418; DOI=10.1186/1471-2121-12-43; PMCID=PMC3209442

Dukes J.D., Whitley P., Chalmers A.D.

The MDCK variety pack: choosing the right strain.

BMC Cell Biol. 12:43.1-43.4(2011)

 

PubMed=24058646; DOI=10.1371/journal.pone.0075014; PMCID=PMC3772841

Lugovtsev V.Y., Melnyk D., Weir J.P.

Heterogeneity of the MDCK cell line and its applicability for influenza virus research.

PLoS ONE 8:E75014-E75014(2013)

 

PubMed=25903999; DOI=10.1002/biot.201400388

Genzel Y.

Designing cell lines for viral vaccine production: where do we stand?

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PubMed=32854295; DOI=10.3390/ijms21176111; PMCID=PMC7504089

Rodrigues A.F., Fernandes P., Laske T., Castro R., Alves P.M., Genzel Y., Coroadinha A.S.

Cell bank origin of MDCK parental cells shapes adaptation to serum-free suspension culture and canine adenoviral vector production.

Int. J. Mol. Sci. 21:6111.1-6111.27(2020)

 

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662

Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.

Transcriptomes of major proximal tubule cell culture models.

J. Am. Soc. Nephrol. 32:86-97(2021)

 

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494

Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.

Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.

Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)