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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
380623-76-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥387.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥216.0 |
| 规格： | 5 mg | 产品价格： | ￥535.0 |
| 规格： | 10 mg | 产品价格： | ￥870.0 |
| 规格： | 25 mg | 产品价格： | ￥1738.0 |
| 规格： | 50 mg | 产品价格： | ￥2475.0 |
| 规格： | 100 mg | 产品价格： | ￥3725.0 |
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SM-7368
CAS No. : 380623-76-7
MCE 国际站：SM-7368
产品活性：SM-7368 是一种 NF-kB 抑制剂，靶向抑制下游的 MAPK p38。SM-7368 还抑制 TNF-α 诱导的 MMP-9 上调。SM-7368 可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。
研究领域：NF-κB | MAPK/ERK Pathway | Metabolic Enzyme/Protease
作用靶点：NF-κB | p38 MAPK | MMP
In Vitro: SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines.
SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.
SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation.
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文献和实验DNA Purification-Modified CTAB Procedure
at the lowest speed that will lightly compress the precipitate. 15.Transfer the precipitate to a 50 ml polypropylene screwcap centrifuge tube containing about 20ml 76% EtOH/10mm NH4Ac; set for about 20 minute. 16.Transfer precipitate to 1.5 ml microtube
an assay sheet SM buffer (optional) (Tip3) glass capillary pipette (optional) Procedure 1. Prepare 10 testing plates and number them on their lids. (#1, 10 for N2; #2, 9 for eat-4 ; # 3-8 for test worms) 2. Take 20-40
锘（nobelium） No 102 (259) 锇（osmium） Os 76 190.2 氧（oxygen） O 8 15.99
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