- ￥600 - 1200
- Proteintech
- APC-65113
- 2025年10月13日
- FC
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
None
- 亚型：
IgG1, kappa
- 保存条件：
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
APC Fluorescent Dye
- 适应物种：
Human
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
CD8a
- 抗体英文名：
APC Anti-Human CD8a (Hit8a)
- 抗体名：
APC Anti-Human CD8a (Hit8a)
- 规格：
25tests/100tests
| 规格： | 25tests | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 100tests | 产品价格： | ￥1200.0 |
经过测试的应用
| Positive FC detected in | human PBMCs |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
APC-65113 targets CD8a in FC applications and shows reactivity with Human samples.
| 经测试应用 | FC |
| 经测试反应性 | Human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | CD8a molecule |
| 别名 | CD8, CD8A, CD8a molecule, Leu2, MAL, p32 |
| 计算分子量 | 235 aa, 26 kDa |
| GenBank蛋白编号 | BC025715 |
| 基因名称 | CD8A |
| Gene ID (NCBI) | 925 |
| ENSEMBL Gene ID | ENSG00000153563 |
| RRID | AB_2883002 |
| 偶联类型 | APC Fluorescent Dye |
| 最大激发/发射波长 | 650 nm / 660 nm |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | P01732 |
| 储存缓冲液 | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
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文献和实验Stimulation of Anti-HIV-1 Cytotoxic T Lymphocytes by Dendritic Cells
Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) in both primary and secondary T-cell responses. This may be related to their expression of high levels of MHC class I and II antigens (1 -4 ), costimulatory
Nature 三连发：竞争消除，有你没我，论癌细胞的「霸道行为」
结直肠癌 (CRC) 是胃肠道中常见的恶性肿瘤，其形成也是一个逐步发展的过程。前期研究数据表明，大多数结直肠癌起始于异常的腺窝，后逐渐演变成息肉，最终发展为结肠直肠癌，整个过程可长达 5 - 15 年。在内在分子机制层面，大多数结直肠癌是通过 WNT 通路的永久激活而启动的，而这种激活通常是发生在肠道干细胞中肿瘤抑制基因 APC 的突变之后。 APC 的突变可诱导肠内细胞增殖增加，防止细胞死亡并阻断分化，所有这些特征均可能有助于提高 APC 突变细胞的相对适应度，APC 突变的肠道干细胞及其后
Preparation of Synchronized Human Cell Extracts to Study Ubiquitination and Degradation
of Xenopus laevis eggs or synchronized human tissue culture cells. Here, we describe protocols to prepare extracts of synchronized human cells, and discuss experiments to use extracts for the biochemical analysis of APC/C-dependent ubiquitination.
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