TBK1 多克隆抗体 28397-1-AP产品图
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TBK1 多克隆抗体 28397-1-AP

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  • ¥1350 - 3000
  • Proteintech已认证
  • 28397-1-AP
  • 2026年05月21日
  • WB, IHC, IF/ICC, ELISA
  • Rabbit
  • human
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 免疫原:

      Recombinant human TBK1 protein

    • 亚型:

      IgG

    • 保存条件:

      Store at -20°C. Stable for one year after shipment.

    • 克隆性:

      Polyclonal

    • 标记物:

      Unconjugated

    • 适应物种:

      human

    • 保质期:

      详见产品包装

    • 库存:

      充足

    • 宿主:

      Rabbit

    • 应用范围:

      WB, IHC, IF/ICC, ELISA

    • 靶点:

      TBK1

    • 抗体英文名:

      TBK1 Polyclonal antibody

    • 抗体名:

      TBK1 Polyclonal antibody

    • 规格:

      50ul/100ul/150ul

    规格:50ul产品价格:¥1350.0
    规格:100ul产品价格:¥2200.0
    规格:150ul产品价格:¥3000.0

    经过测试的应用

    Positive WB detected inHT-1080 cells, HCT 116 cells, HeLa cells, HepG2 cells, U2OS cells
    Positive IHC detected inhuman stomach cancer tissue, human liver cancer tissue
    Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
    Positive IF/ICC detected inMCF-7 cells
    Planning an IHC experiment? We recommend our IHCeasy® TBK1 Ready-To-Use IHC Kit. TBK1 primary antibody included.

    推荐稀释比

    应用推荐稀释比
    Western Blot (WB)WB : 1:500-1:2000
    Immunohistochemistry (IHC)IHC : 1:50-1:500
    Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
    It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    28397-1-AP targets TBK1 in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human samples.

    经测试应用 WB, IHC, IF/ICC, ELISA
    文献引用应用WB, IHC, IP
    经测试反应性 human
    文献引用反应性human, mouse, rat, pig, monkey, chicken, bovine, hamster
    免疫原

    CatNo: Ag28894

    Product name: Recombinant human TBK1 protein

    Source: e coli.-derived, PET28a

    Tag: 6*His

    Domain: 316-576 aa of BC034950

    Sequence: LQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLA

    宿主/亚型 Rabbit / IgG
    抗体类别 Polyclonal
    产品类型 Antibody
    全称 TANK-binding kinase 1
    别名 EC:2.7.11.1, NF kappa B activating kinase, NF-kappa-B-activating kinase, Serine/threonine protein kinase TBK1, Serine/threonine-protein kinase TBK1
    观测分子量 84 kDa
    GenBank蛋白编号BC034950
    基因名称 TBK1
    Gene ID (NCBI) 29110
    RRIDAB_2881132
    偶联类型 Unconjugated
    形式Liquid
    纯化方式Antigen affinity purification
    UNIPROT IDQ9UHD2
    储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
    储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

    背景介绍

    TBK1, also named as tumor necrosis factor (TNF) receptor-associated factor NF-kB activator (TANK)-binding kinase 1 (TBK1), NF-kB-activating kinase (NAK), T2K, is a multimeric kinase that modulates inflammation and autophagy. It is a ubiquitously expressed serine-threonine kinase belonging to the 'noncanonical IkB kinases' (IKKs) recognized for its critical role in regulating type I IFN production (PMID: 27211305). And TBK1 is an important player in yet another critical cellular function, autophagy. This antibody is specific for TBK1.

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    图标询价记录
    图标暂无询价记录
    图标文献和实验
    该产品被引用文献
    [1]Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.
    PMID:41637663FASEB J2026-02-15
    [2]Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
    PMID:41480826Aging Cell2026-01
    [3]Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells.
    PMID:40412527J Biol Chem2025-07
    [4]AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3.
    PMID:40085973Redox Biol2025-05
    [5]β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy.
    PMID:39891248J Anim Sci Biotechnol2025-02-01
    [6]Activation of cGAS confers PARP inhibitor resistance in ovarian cancer via the TBK1-IRF3 axis.
    PMID:39660334Int J Clin Exp Pathol2024-11-15
    [7]CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer
    PMID:38861362Cancer Res2024-08-15
    [8]Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
    PMID:38636706Virol Sin2024-06
    [9]A role of STING signaling in obesity-induced lung inflammation.
    PMID:36782056Int J Obes (Lond)2023-04
    [10]Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
    PMID:36030554J Clin Lab Anal2022-10
    相关实验
    • 【进展】Nature Immunology:发现具有抑制致炎细胞因子蛋白

      cytokines but increased interferon-production in Toll-like receptor–triggered macrophages by suppressing adaptor MyD88–dependent activation of transcription factors NF-B and AP-1 while promoting activation of the kinase TBK1 and transcription factor IRF

    • 有适合免疫沉淀IP的GST抗体吗?

      因此,综合来说,EarthOx的GST标签抗体 (货号#E022040)是一款同时具有高特异性、高灵敏度、多应用类型以及性价比的GST标签抗体。同时,我们也提供其他品牌的GST标签抗体,如Proteintech的GST多克隆抗体 ――GST PolyClonal Antibody(货号#10000-0-AP)以及Abcam、Santa等多种GST标签抗体产品。更多GST标签抗体以及其他如His、HA、Myc、GFP、Flag等其他标签抗体,请电话垂询。美国EarthOx品牌是一家提供高性价比免疫学和细胞

    • 抗体选择

      实验,请根据说明书列出已验证的种属来选择适合你实验的抗体。   (4)样本蛋白的结构性质。了解样本蛋白的结构性质有助于选择最合适的抗体,待测样本蛋白的结构域和样本在提取和处理过程中是否会变性,蛋白空间构象的改变,会影响抗体的免疫亲和反应。   (5)单多克隆抗体的选择。市面上的抗体还是以多克隆抗体为主,一般单克隆抗体特异性强,但亲和力相对小,检测抗原灵敏度相对就低;而多克隆抗体特异性稍弱,但抗体的亲和力强,灵敏度高,但易出现非特异性染色(可以通过封闭等避免

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    TBK1 多克隆抗体 28397-1-AP
    ¥1350 - 3000