CACNA2D2 多克隆抗体

免疫组织化学（IHC）已验证样本:Human esophagus cancer

IHC 1:30-1:150, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human CACNA2D2

CACNA2D2

Alpha 2 delta calcium channel subunit;CA2D2;CACNA2D;Cacna2d2;Calcium channel;voltage-dependent;alpha 2/delta subunit 2;Calcium channel;voltage-dependent;alpha 2/delta subunit 2 gene 26;Calcium voltage gated channel auxiliary subunit alpha2delta 2;Gene 26;KIAA0558;LUAC11.1;Voltage-dependent calcium channel subunit alpha-2/delta-2;Voltage-dependent calcium channel subunit delta-2;Voltage-gated calcium channel subunit alpha-2/delta-2抗体

Q9NY47

Membrane. Colocalizes with CACNA1A in lipid raft fractions.

0.7 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cell Biology; Neuroscience; Signal Transduction

Unconjugated

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.