- 询价
- Cell Signaling Technology
- 2229
- USA
- 2025年08月08日
- W
- Rabbit
- H,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Toll-like Receptor 2 Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Leu179 of human TLR2 protein
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,Mk
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H Mk | Endogenous | 95 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Toll-like Receptor 2 Antibody detects endogenous levels of total TLR2 protein. Cross reactivity was not detected with other family members at physiological conditions. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu179 of human TLR2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from THP-1 cell lines, stimulated with 200 µM TPA overnight, using Toll-like Receptor 2 Antibody. |
| Background | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila , play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasm. |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Pyrosequencing of Toll-Like Receptor Polymorphisms of Functional Relevance
may influence the development of inflammatory diseases. Members of the ‘toll-like receptor’ (TLR) family are pivotal molecules in the activation of the innate immune system and specifically recognize structurally conserved pathogen-associated molecular patterns
Microarray Experiments to Uncover Toll-Like Receptor Function
This chapter is intended as a handbook for anyone interested in using microarrays to study Toll-like receptor (TLR) function or any other biological question. Although microarray technology has developed into a standard tool
Bioinformatic Analysis of Toll-Like Receptor Sequences and Structures
. In the context of Toll-interleukin-1 receptor (TIR) domain containing proteins, we describe here a series of the more common and user-friendly bioinformatic tools available as internet-based resources. These will enable the identification and alignment of protein
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