- 询价
- Cell Signaling Technology
- 9152
- USA
- 2025年08月15日
- W, IP
- Rabbit
- H,M,R,Mk,Dg
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- 详细信息
- 技术资料
- 抗体英文名：
SEK1/MKK4 Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding the N-terminus of human SEK1/MKK4
- 应用范围：
W, IP
- 宿主：
Rabbit
- 保质期：
详见说明书
- 适应物种：
H,M,R,Mk,Dg
- 级别：
详见MSDS文件
- 供应商：
CST
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R Mk (Dg) | Endogenous | 44 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | SEK1/MKK4 Antibody detects endogenous levels of total SEK1/MKK4 protein. This antibody does not cross-react with MEK1, MEK2 or MKK3. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the N-terminus of human SEK1/MKK4. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HEK293, NIH/3T3, C6, COS and A431 cells, using SEK1/MKK4 Antibody. |
| Background | SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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