- 询价
- Cell Signaling Technology
- 4845
- USA
- 2025年09月02日
- W
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
RANK Antibody
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of RANK
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 适应物种：
H,M,R
- 级别：
详见MSDS文件
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 80 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | RANK Antibody detects endogenous levels of RANK protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of RANK. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from K562 (human), KNRK (rat) and C2C12 (mouse) cell lines, using RANK Antibody. Western Blotting
Western blot analysis of extracts from HeLa cells mock transfected or transfected with mRANK, using RANK Antibody. |
| Background | RANK (receptor activator of NF-κB) is a member of the tumor necrosis factor (TNF) receptor subfamily that is activated by its ligand, RANKL (TRANCE/OPGL/ODF), to promote survival of dendritic cells and differentiation of osteoclasts (1-4). Although RANK is widely expressed, its cell surface expression may be more restricted to dendritic cells and foreskin fibroblasts (1). RANK contains a 383-amino acid intracellular domain that associates with specific members of the TRAF family to NF-κB and JNK activiation (1,5). RANKL/RANK signaling may also lead to survival signaling through activation of the Akt pathway and an upregulation of survival proteins, including Bcl-xL (2,6). RANK signaling has been implicated as a potential therapeutic to inhibit bone loss and arthritis (7,8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验是指分类学上所设立的规定各群相互位置的等级。以种为基本单位，向大分类群和小分类群的两个方面，也就是向上和向下加以规定。分类群的表示大体上规定一定的词尾以便于理解，并且在必需的等级之外，必要时还设立中间等级，在其下面再加设时则冠以亚字（ sub－）。而动物分类则限定在上面设立，这时各冠以总字（ supra－）。另外有设立补充等级的。在动物分类为 brigade， cohort， legion， section；植物分类在亚系（ subseries）之下
Kinetic Screening in the Antibody Development Process
. The method uses a single injection of one antigen concentration for the determination of six relevant screening parameters, which comprehensively describe the antibody’s kinetic rate profile and its valence mode. The method enables the scientist to rank
Power of the Rank Test for Multi-Strata Case-Control Studies with Ordinal Exposure Variables
In epidemiological studies of rare diseases (i.e., rare types of cancer) researchers often face major difficulty in obtaining enough cases of the disease to make valid comparisons using odds-ratio estimators. Moreover, they may wish to adjust
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