- 询价
- Cell Signaling Technology
- 2464
- USA
- 2025年12月04日
- W, IP
- Rabbit
- H
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- 详细信息
- 技术资料
- 抗体英文名：
PTCH2 (L849) Antibody
- 抗原：
synthetic peptide corresponding to a region (predicted to be extracellular) surrounding residue Leu849 of human PTCH2
- 应用范围：
W, IP
- 宿主：
Rabbit
- 库存：
大量
- 供应商：
CST
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 适应物种：
H
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H | Transfected Only | 130 kDa | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | PTCH2 (L849) Antibody detects transfected levels of PTCH2 protein. It does not recognize transfected levels of human PTCH1. This antibody also cross-reacts with an unidentified protein at 55 kDa. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region (predicted to be extracellular) surrounding residue Leu849 of human PTCH2. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of total cell lysates from COS cells and COS cells transiently transfected with a construct expressing human PTCH2 using PTCH2 (L849) Antibody. |
| Background | Patched1 and 2 (PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the receiving receptors for members of the Hedgehog family of proteins (1-4). In the absence of Hedgehog proteins, PTCH suppresses the otherwise constitutively active signaling receptor Smoothened (Smo) so that the Hedgehog signaling pathway is in the off state (5,6). Deactivating mutations that impair the ability of PTCH1 to suppress Smo are frequently found in patients with nevoid basal cell carcinoma syndrome (7,8). PTCH proteins have a sterol-sensing domain (SSD) also found in several proteins that function in cholesterol homeostasis, such as HMGCR (3-hydroxy-3-methylglutaryl coenzyme A-reductase) and SCAP (sterol regulatory element-binding protein-cleavage activating protein). However, the role of the SSD in Patched proteins is not clear (9,10).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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