- 询价
- Cell Signaling Technology
- 2132
- USA
- 2025年08月11日
- W
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Parkin Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding amino acid 400 of human parkin
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 适应物种：
H,M,R
- 级别：
详见MSDS文件
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 52 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Parkin Antibody detects endogenous levels of total parkin protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 400 of human parkin. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from parkin-transfected SH-SY5Y cells (lane 1), untransfected SH-SY5Y cells (lane 2) and C6 cells (lane 3), using Parkin Antibody. |
| Background | Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin (2). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Semiquantitative PCR for the Detection of Exon Rearrangements in the Parkin Gene
Mutations in the parkin gene have been shown to be responsible for a substantial number of cases of autosomal recessive early onset parkinsonism (AR-JP, PARK2, OMIM 602544) worldwide (1 –4 ). The gene on chromosome 6q25.2-27 consists of 12
Parkinsons Disease: Assays for the Ubiquitin Ligase Activity of Neural Parkin
The identification of monogenic variants of Parkinson’s disease (PD) has provided novel insights into its unknown pathogenesis. As the first protein linked to autosomal-recessive forms of PD, Parkin became a welcome tool to explain
日本研究人员日前宣布，体内两种基因变异，导致线粒体“次品”在细胞内堆积，是造成青年型帕金森氏症发病的原因。 帕金森氏症患者会出现手脚震颤等运动障碍，给患者的日常生活造成很大困难。目前，日本国内有将近15万名患者，其中大半是老年病人，但其中也有10％左右是40岁以前发病的所谓青年型帕金森氏症患者。 此前的研究表明，如果“Parkin”和“PINK1”这两种基因出现变异，人在年轻时期就会患上帕金森氏症。 东京都临床医学综合研究所与顺天堂大学的研究人员共同研究了上述两种基因。他们发现，两种基因
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