- 询价
- Cell Signaling Technology
- 3542
- USA
- 2025年08月07日
- W, IHC-P
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
NPM Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding the amino-terminus of human NPM
- 应用范围：
W, IHC-P
- 宿主：
Rabbit
- 库存：
大量
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 适应物种：
H,M,R
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IHC-P | H M R | Endogenous | 38 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | NPM Antibody detects endogenous levels of total NPM protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino-terminus of human NPM. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from SW-13, NIH/3T3, Jurkat and PC12 cells, using NPM Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, showing nuclear localization, using NMP Antibody. IHC-P (paraffin)
Im munohistochemical analysis of paraffin-embedded human colon carcinoma, using NPM Antibody in the presence of control peptide (left) or antigen-specific peptide (right). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using NPM Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human metastatic adenocarcinoma, in lymph node, using NPM Antibody. |
| Background | Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities (1,2). The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase (3,4). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Molecular Genetic Tests for FLT3, NPM1, and CEBPA in Acute Myeloid Leukemia
in FLT3 (FMS-like tyrosine kinase 3), NPM1 (Nucleophosmin), and CEBPA (CCAAT/enhancer-binding protein alpha) genes hold prognostic significance in patients with AML and normal cytogenetics. Therefore, mutation identification may help to optimize
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
6/LAZ3 zinc finger gene located at 3q27 (altered in approx 30% of large-cell lymphomas [2 –4 ]) and the NPM-ALK fusion gene (5 –7 ) produced by the t(2;5)-have been analyzed to now permit the identification of patient subsets that have reproducibly
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