- 询价
- Cell Signaling Technology
- 4062
- USA
- 2025年08月29日
- W
- Rabbit
- H,M,R,Mk,B
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Mst3b Antibody
- 抗原：
synthetic peptide corresponding to the amino-terminal residues of human Mst3b
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
H,M,R,Mk,B
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Mk B | Endogenous | 59 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Mst3b Antibody detects endogenous levels of total Mst3b. The antibody does not cross-react with Mst3, Mst1, Mst2 or Mst4. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal residues of human Mst3b. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa cells treated with staurosporine for the indicated times, using Mst3b Antibody. Western Blotting
Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using Mst3b Antibody. |
| Background | Mst kinases, members of the STE20 family of kinases, are upstream activators of MAPK pathways that regulate processes such as apoptosis, morphogenesis and cytoskeletal rearrangements. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases (1). The carboxy-terminal region of Mst1 and Mst2 contains dimerization and inhibitory domains (1-3). Dimerization and phosphorylation at the activation loop results in translocation of Mst1 from the cytosol to the nucleus (3). Growing evidence indicates that Mst1, Mst2 and Mst3 are activated by apoptotic signals as well as other stress conditions (4-6). Complete activation of Mst1 requires both phosphorylation and caspase-mediated cleavage (4). Sequence alignment of the activation loop of the GCK family indicates that Thr183 of Mst1 and Thr180 of Mst2 are the conserved residues and might be critical for the activity of the kinases. Activated Mst kinases may rely on p38 MAPK and JNK pathways to amplify apoptotic signals (5). Phosphorylation at Ser327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage (4). Mst3b, an isoform of Mst3, is reported to be regulated by PKA (7).
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| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验化，其他已知细胞松弛素 B还可抑制糖的输送，可以考虑细胞松弛素 B与细胞膜间的相互作用。此外还分离出数种具有类似结构和功能的物质，分别命名为细胞松弛素 A、 C、 D、 E、 F。
细胞色素b563 cytochrome b563 亦称细胞色素 b6 。存在于高等植物至藻类的叶绿体中，与类囊体膜结合紧密。含有原正铁血红素，氧化还原 （β带）和 434nm（γ带或 So－ ret带）。为发动光合磷酸化的环状电子传递系统的一个成分，可被光化系统Ⅰ所还原和氧化。
Antibody-Induced Opsonophagocytosis of Serogroup B Meningococci Measured by Flow Cytometry
meningococci, there seems to be a correlation between SBA activity and protection (1 ), whereas OP has been less well-studied. This function may have a supplementary or even major role in protection against group B meningococci.
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