- ￥13785.15
- Sigma-Aldrich
- C7521
- made in USA
- 2025年12月02日
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
1年
- 保存条件：
-20°C
- 库存：
30⁺瓶
- 供应商：
上海睿安生物19121878899
- 规格：
50mg/瓶
Sigma货号C7521-5mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Sigma货号C7521-10mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Sigma货号C7521-50mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Human Collagen Type IV
from human placenta,powder,suitable for substrate for collagenase and for diagnostic assay manufacturing
别名:4型胶原蛋白
说明
生化/生理作用
在发育过程中，胶原蛋白IV普遍分布在BM中。 在成熟过程中，该网状纤维以显著的组织特异性方式被部分替换，从而定义BM结构和功能。 胶原蛋白IV可以结合血小板、肝细胞、角质形成细胞、内皮细胞、肾小球膜细胞、胰腺细胞以及一些肿瘤细胞。
制备说明
本品为冻干粉末，能够以1mg/ml的浓度重悬于无菌的.5M乙酸、PBS或水中。 PBS能够在-20℃情况下稳定保存至少一年。它是通过改良版Glanville,R.W.,et al胃蛋白酶提取蛋白制备的。
分析说明
SDS聚丙(bǐng)烯酰胺凝胶电泳在和基底膜胶原蛋白相同的还原条件下测试，得到三条主要条带。
其他说明
所有胶原蛋白分子均由以三螺旋构象排列的三条肽链组成，其一级结构主要以三个氨基酸作为重复基序，即每隔两个氨基酸是一个甘氨酸残基，其前面的两个位置通常为脯氨酸或4-羟基脯氨酸。IV型胶原仅存在于基底膜中，并含有多达六条基因不同的a链。
胶原蛋白被分为许多种结构和遗传性不同的类型。 我们使用Bornstein和Traub提出的系统命名法。小心不要混淆Sigma命名系统和通用的胶原蛋白分类类型。
同行评审论文(部分:文献)
Albocollagenase, a novel recombinant P-III snake venom metalloproteinase from green pit viper (Cryptelytrops albolabris), digests collagen and inhibits platelet aggregation.
Anuwat Pinyachat et al.
Toxicon : official journal of the International Society on Toxinology, 57(5), 772-780 (2011-02-22)
Molecular cloning and functional characterization of P-III snake venom metalloproteinases (SVMPs) will give us deeper insights in the pathogenesis of viper bites. This may lead to novel therapy for venom-induced local tissue damages, the complication refractory to current antivenom. The
Novel human bronchial epithelial cell lines for cystic fibrosis research.
M L Fulcher et al.
American journal of physiology. Lung cellular and molecular physiology, 296(1), L82-L91 (2008-11-04)
Immortalization of human bronchial epithelial (hBE) cells often entails loss of differentiation. Bmi-1 is a protooncogene that maintains stem cells, and its expression creates cell lines that recapitulate normal cell structure and function. We introduced Bmi-1 and the catalytic subunit
UHRF1 is required for basal stem cell proliferation in response to airway injury.
Handan Xiang et al.
Cell discovery, 3, 17019-17019 (2017-06-20)
Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the
Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.
Marion Jeanne et al.
Circulation, 131(18), 1555-1565 (2015-03-11)
Collagen type IV alpha1 (COL4A1) and alpha2 (COL4A2) form heterotrimers critical for vascular basement membrane stability and function. Patients with COL4A1 or COL4A2 mutations suffer from diverse cerebrovascular diseases, including cerebral microbleeds, porencephaly, and fatal intracerebral hemorrhage (ICH). However, the
EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair.
Nguyen Thu Ngan Trinh et al.
American journal of physiology. Lung cellular and molecular physiology, 295(5), L866-L880 (2008-09-02)
Severe lesions of airway epithelia are observed in cystic fibrosis (CF) patients. The regulatory mechanisms of cell migration and proliferation processes, involved in the repair of injured epithelia, then need to be better understood. A model of mechanical wounding of
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文献和实验该产品被引用文献
Sigma货号C7521-5mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Sigma货号C7521-10mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Sigma货号C7521-50mg胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)19121878899上海睿安生物
Human Collagen Type IV
from human placenta,powder,suitable for substrate for collagenase and for diagnostic assay manufacturing
别名:4型胶原蛋白
说明
生化/生理作用
在发育过程中，胶原蛋白IV普遍分布在BM中。 在成熟过程中，该网状纤维以显著的组织特异性方式被部分替换，从而定义BM结构和功能。 胶原蛋白IV可以结合血小板、肝细胞、角质形成细胞、内皮细胞、肾小球膜细胞、胰腺细胞以及一些肿瘤细胞。
制备说明
本品为冻干粉末，能够以1mg/ml的浓度重悬于无菌的.5M乙酸、PBS或水中。 PBS能够在-20℃情况下稳定保存至少一年。它是通过改良版Glanville,R.W.,et al胃蛋白酶提取蛋白制备的。
分析说明
SDS聚丙(bǐng)烯酰胺凝胶电泳在和基底膜胶原蛋白相同的还原条件下测试，得到三条主要条带。
其他说明
所有胶原蛋白分子均由以三螺旋构象排列的三条肽链组成，其一级结构主要以三个氨基酸作为重复基序，即每隔两个氨基酸是一个甘氨酸残基，其前面的两个位置通常为脯氨酸或4-羟基脯氨酸。IV型胶原仅存在于基底膜中，并含有多达六条基因不同的a链。
胶原蛋白被分为许多种结构和遗传性不同的类型。 我们使用Bornstein和Traub提出的系统命名法。小心不要混淆Sigma命名系统和通用的胶原蛋白分类类型。
同行评审论文(部分:文献)
Albocollagenase, a novel recombinant P-III snake venom metalloproteinase from green pit viper (Cryptelytrops albolabris), digests collagen and inhibits platelet aggregation.
Anuwat Pinyachat et al.
Toxicon : official journal of the International Society on Toxinology, 57(5), 772-780 (2011-02-22)
Molecular cloning and functional characterization of P-III snake venom metalloproteinases (SVMPs) will give us deeper insights in the pathogenesis of viper bites. This may lead to novel therapy for venom-induced local tissue damages, the complication refractory to current antivenom. The
Novel human bronchial epithelial cell lines for cystic fibrosis research.
M L Fulcher et al.
American journal of physiology. Lung cellular and molecular physiology, 296(1), L82-L91 (2008-11-04)
Immortalization of human bronchial epithelial (hBE) cells often entails loss of differentiation. Bmi-1 is a protooncogene that maintains stem cells, and its expression creates cell lines that recapitulate normal cell structure and function. We introduced Bmi-1 and the catalytic subunit
UHRF1 is required for basal stem cell proliferation in response to airway injury.
Handan Xiang et al.
Cell discovery, 3, 17019-17019 (2017-06-20)
Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the
Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.
Marion Jeanne et al.
Circulation, 131(18), 1555-1565 (2015-03-11)
Collagen type IV alpha1 (COL4A1) and alpha2 (COL4A2) form heterotrimers critical for vascular basement membrane stability and function. Patients with COL4A1 or COL4A2 mutations suffer from diverse cerebrovascular diseases, including cerebral microbleeds, porencephaly, and fatal intracerebral hemorrhage (ICH). However, the
EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair.
Nguyen Thu Ngan Trinh et al.
American journal of physiology. Lung cellular and molecular physiology, 295(5), L866-L880 (2008-09-02)
Severe lesions of airway epithelia are observed in cystic fibrosis (CF) patients. The regulatory mechanisms of cell migration and proliferation processes, involved in the repair of injured epithelia, then need to be better understood. A model of mechanical wounding of
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三句话读懂一篇 CNS，胎盘其实更像肿瘤组织，可能是遗传缺陷和不良妊娠之源...
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电压门控钠离子通道（Nav）位于细胞膜上，选择性地将 Na + 渗透到整个细胞膜上，通过引发和传导动作电位参与肌肉收缩，神经信号传递等重要生理过程。目前已经发现人类 Nav 有 9 个亚型（Nav 1.1 至 Nav 1.9），这些离子通道的功能异常与癫痫、疼痛综合征、心脏相关疾病等多种疾病相关。颜宁团队多年来始终致力于 Nav 通道的结构生物学研究，取得了一系列研究成果，多篇文章发表在 Nature、Science、PNAS 等期刊上。然而以往的研究多是在细菌的钠离子通道晶体结构解析，少有
文献支持
Sigma货号C7521胶原蛋白(Human Collagen Type IV)来源于人类胎盘(别名:4型胶原蛋白)
￥13785.15
