- 询价
- Cell Signaling Technology
- 4928
- USA
- 2025年09月05日
- W, E-P
- Rabbit
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Granzyme A Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding threonine 121 of human Granzyme A
- 应用范围：
W, E-P
- 宿主：
Rabbit
- 级别：
详见MSDS文件
- 供应商：
CST
- 适应物种：
H
- 库存：
大量
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting E-P=ELISA (Peptide)
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W E-P | H | Endogenous | 28 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Granzyme A Antibody detects endogenous levels of Granzyme A protein. No cross-reactivity was observed with Granzyme B. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding threonine 121 of human Granzyme A. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of recombinant His-tagged Granzyme A (10 ng) and lysates from the natural killer cell line NK-92, using Granzyme A Antibody. ELISA-Peptide
ELISA analysis of plates coated with recombinant human Granzyme A, using Granzyme A Antibody. |
| Background | Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验相关专题 白介素21在自体免疫 和癌症中扮演的角色。Role of IL-21 in autoimmunity and cancer. IL-21 is involved in reciprocal cross talk between disparate cell types, leading to effects on innate immune responses and adaptive antibody
ELISPOT (Enzyme-linked ImmunoSPOT) 实验方法步骤
of cytokine-producing cells at the single cell level. The method employs the sandwich assay approach of the enzyme-linked immunosorbent assay (ELISA), with some variations. The ELISPOT capture antibody is coated aseptically onto a polyvinylidene difluoride
ELISPOT (Enzyme-linked ImmunoSPOT)
Human ELISPOT Ready-Set-Go! Sets & Antibody Selection Quick Guide Human Cytokine ELISPOT Set Catalog No. Capture mAb Detection mAb Granzyme B 88-8399 eBioGrB
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