- 询价
- Cell Signaling Technology
- 2175
- USA
- 2025年08月21日
- W
- Rabbit
- H,M,R,Mk,B,Dg
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Cyclophilin A Antibody
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of Cyclophilin A
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 库存：
大量
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk,B,Dg
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey B=Bovine Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Mk (B) (Dg) | Endogenous | 18 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Cyclophilin A Antibody detects endogenous levels of total Cyclophilin A protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of Cyclophilin A. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa (human), NIH/3T3 (mouse) and KNRK (rat) cell lines, using Cyclophilin A Antibody. |
| Background | Cyclophilins are a highly conserved family of peptidylprolyl cis -trans -isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA) (1,2). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines (3,4). As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection (5,6). There is also some evidence that cyclophilins have nuclease activity and play a role in apoptosis (7).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验.Anticyclophilin autoantibodies were found in 48% of the SLE patients. The positive rate of IgG, IgA and IgM anti-cyclophilin A antibody is 36%, 20% and 18%, respectively. The prevelance of antibodies to CyPA in patients with skin and mucous lesion, leukopenia
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mitochondrial transition pore formation by binding cyclophilin D. The Image-iT LIVE Mitochondrial Transition Pore Assay Kit has been tested with HeLa cells and bovine pulmonary artery endothelial cells (BPAEC). Each Image-iT LIVE Mitochondrial Transition Pore
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