- 询价
- Cell Signaling Technology
- 2031
- USA
- 2025年10月11日
- W
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Cleaved Lamin A (Asp230) Antibody
- 抗原：
synthetic peptide corresponding to carboxy-terminal residues surrounding Asp230 in human lamin A
- 应用范围：
W
- 宿主：
Rabbit
- 供应商：
CST
- 库存：
大量
- 适应物种：
H,M,R
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 45, 50 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Cleaved Lamin A (Asp230) Antibody detects endogenous levels of the large fragment of lamin A (and lamin C isotype) resulting from cleavage at aspartic acid 230. The antibody does not recognize full length lamin A. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues surrounding Asp230 in human lamin A. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa cells, untreated or staurosporine-treated (1 µM), using Cleaved Lamin A (Asp230) Antibody (upper) or Lamin A Antibody #2032 (lower). |
| Background | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6). (This product is sold under license from Promega Corp., U.S. Patent No. 6,350,452.)
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验或 C6 cells 作为 cleaved caspase-3 的阳性参照。更多靶点的阳性对照，请登陆CST网站——研究——靶标的阳性对照处理。图二 蛋白质印迹分析（图源自CST Caspase-3 Antibody #9662 抗体说明书）为什么所有的实验都要设置对照？无论是初高中刚接触生物学实验设计还是上研究生后发表 SCI 文章，老师们以及 reviewer 都会敲着「黑板」强调强调再强调，每一个实验都必须有对照！因为设置适当的阴性、阳性甚至空白对照对于实验结果的准确、有效阐释至关重要！阅历丰富
of icosahedral phage particle which contains the viral genome: During replication, the phage DNA is produced in a concatameric form, which is cleaved by appropriate endonucleases to allow packaging of a single genome within the phage
线粒体荧光探针大全：TMRM，Mitotracker，JC-1
such as DASPMI (4-Di-1-ASP, D288), which may take 30 minutes or longer.14 Viewed through a fluorescein longpass optical filter (Table 23.12), fluorescence of the mitochondria of cells stained by rhodamine 123 appears yellow-green. Viewed
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