- 询价
- Cell Signaling Technology
- 2410
- USA
- 2025年08月28日
- W, IF-IC
- Rabbit
- H,M,R,Mk,B
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Clathrin Heavy Chain (P1663) Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Pro1663 of human Clathrin
- 应用范围：
W, IF-IC
- 宿主：
Rabbit
- 供应商：
CST
- 库存：
大量
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 适应物种：
H,M,R,Mk,B
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IF-IC | H M R Mk B | Endogenous | 190 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Clathrin Heavy Chain (P1663) Antibody detects endogenous levels of total Clathrin protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1663 of human Clathrin. Antibodies are purified by protein A and peptide affinity chromatography Western Blotting
Western blot analysis of extracts from SHSY5Y, Neuro2A, PC12 and COS cells, using Clathrin Heavy Chain (P1663) Antibody. IF-IC
Confocal immunofluorescent analysis of HeLa cells labeled with Clathrin Heavy Chain (P1663) Antibody (green). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye). |
| Background | Clathrin-coated vesicles provide for the intracellular transport of cargo proteins following endocytosis and during multiple vesicle trafficking pathways. Vesicles form at specialized areas of the cell membrane where clathrin and associated proteins form clathrin-coated pits. Invagination of these cell membrane-associated pits internalizes proteins and forms an intracellular clathrin-coated vesicle (1,2). Clathrin is the most abundant protein in these vesicles and is present as a basic assembly unit called a triskelion. Each clathrin triskelion is composed of three clathrin heavy chains and three clathrin light chains. Clathrin heavy chain proteins are composed of several functional domains, including a carboxy-terminal region that permits interaction with other heavy chain proteins within a triskelion, and a globular amino-terminal region that associates with other vesicle proteins (2). Adaptor proteins, such as AP2, epsin and EPS15, are responsible for the recruitment of vesicle proteins to sites of pit formation and the assembly of the clathrin-coated vesicle. Following vesicle invagination, the GTPase dynamin constricts the neck of the nascent vesicle to complete formation of the free, cytosolic vesicle (3,4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Production of Chimeric Heavy-Chain Antibodies
of fragment crystallizable (Fc), which is known to be crucial for a long serum half-life through binding to FcRn and antibody-mediated cell killing through binding to Fcγ receptors and complement. Single-domain antibodies (sdAbs) derived from camelid heavy
Introduction to Heavy Chain Antibodies and Derived Nanobodies
The immune response of infected or immunized dromedaries contains a diverse repertoire of conventional and heavy chain-only antibodies, both functional in antigen binding. By definition, a heavy chain antibody is devoid of a light chain
Stable Expression of Chimeric Heavy Chain Antibodies in CHO Cells
Camelid single domain antibodies fused to noncamelid Fc regions, also called chimeric heavy chain antibodies (cHCAb), offer great potential as therapeutic and diagnostic candidates due to their relatively small size (80 kDa) and intact Fc
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