ABT-724 (hydrochloride)

多巴胺D4受体激动剂（使用表达人类D4.4受体和Gαqo5的HEK293细胞进行FLIPR钙流测定时EC50=12.4nM）；10μM时对多巴胺D4受体的选择性优于D2受体；0.03μmol/kg时可诱发77%雄性大鼠的阴茎勃起；0.04mg/kg时可降低雄性大鼠的交配频率和射精潜伏期，增加射精频率和交配效力；0.16和0.64mg/kg时可降低青少年SHRADHD模型在旷场测试中的多动和探索行为。A dopamine D4 receptor agonist (EC50 = 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5); selective for dopamine D4 over D2 receptors at 10 μM; induces penile erections in 77% of male rats at 0.03 μmol/kg; decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats at 0.04 mg/kg; decreases hyperactivity and exploratory behavior in the open field test in an adolescent SHR model of ADHD at 0.16 and 0.64 mg/kg.