DCEBIO

IKCa1/KCa3.1通道的激活剂；以浓度依赖性方式激活IKCa1/KCa3.1并诱导T84单层细胞中氯离子的分泌；增强SK通道的活性（在表达重组人SK2通道的HEK293细胞中，EC50=27µM）；在100µM时增强CA1锥体神经元中SK通道介导的IAHP；诱导小鼠空肠分离物中氯离子的分泌（EC50=41µM）。An activator of IKCa1/KCa3.1 channels; activates IKCa1/KCa3.1 and induces chloride secretion in T84 monolayers in a concentration-dependent manner; potentiates the activity of SK channels (EC50 = 27 µM in HEK293 cells expressing recombinant human SK2 channels); potentiates SK channel-mediated IAHP in CA1 pyramidal neurons at 100 µM; induces chloride secretion in isolated mouse jejunum (EC50 = 41 µM).