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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human OGG1/N-Glycosylase/DNA lyase
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥840.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2520.0 |
| 规格： | 500ug | 产品价格： | 询价 |
| 规格： | 1mg | 产品价格： | 询价 |
产品说明(Description)
Recombinant Human N-Glycosylase is produced by our E.coli expression system and the target gene encoding Met1-Gly345 is expressed with a GST tag at the N-terminus.
Accession #: AAH00657.1
Known as: N-Glycosylase/DNA Lyase; 8-Oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1
制剂（Formulation）
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.
质量控制（Quality Control）
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
运输（Shipping）
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存（Storage）
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景（Background）
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY
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文献和实验【求助】5'-deoxyribose-5-phosphate(5'-dRP) lyase以及5'-dRP/AP lyase的概念
of a damaged base requires the concerted activities of a glycosylase to remove the damaged or inappropriate base, a class II apurinic/apyrimidinic (AP) endonuclease to incise the DNA 5′ to the AP site, a lyase activity to remove the 5′ terminal 2-deoxyribose-5
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Hydroxynitrile lyase (MeHNL, EC 4.1.2.39) is a useful enzyme for production of optically active cyanohydrin compounds. Production of MeHNL can be increased by substituting rare codons of the natural sequence of cassava (Manihot esculenta
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