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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20°C, sealed storage, away from moisture
- 英文名:
CEBPA-51
- 库存:
货期:询盘
- 供应商:
MedChemExpress LLC
- CAS号:
2862057-05-2
- 规格:
询盘
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MTL-CEBPA
CAS No. : 2862057-05-2
MCE 国际站:MTL-CEBPA
产品活性:MTL-CEPBA 是一种靶向 C/EBPα 上调的小活化 RNA。MTL-CEPBA 具有抗炎和抗癌活性。
研究领域:Epigenetics
作用靶点:MicroRNA
In Vitro: MTL-CEBPA does not significantly change total human CD45+ cells, and T lymphocytes (hCD4+ and hCD8+ T cell subsets) in PB. However, MTL-CEBPA treatment increases CD16+ granulocytes and CD14+ monocytes in peripheral blood (PB).
In Vivo: MTL-CEBPA (iv; 3 mg/kg; on days 1, 3, and 5) demonstrates the specific activation of its target C/EBPα mRNA and its downstream gene p21 in naive hu-NSG mice.
MTL-CEBPA restores LPS-induced (12.5 μg; ip; single dose) reduction of C/EBPα and downregulates several genes associated with immune and inflammatory response in an LPS-stimulated humanized NSG model.
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文献和实验博士试图将癌症治疗中的 RNA 疗法用于新冠肺炎患者的治疗,并成功开发了基于小激活 RNA(small activating RNA,saRNA)抑制病毒扩增策略和基于 saRNA 的 MTL-CEBPA 阻止细胞因子风暴策略。 小激活 RNA(small activating RNAs) 与 RNAi 的沉默效果相比,RNAa 的激活作用更为持久,故 saRNA 已经成为基因治疗领域重要工具之一,为肿瘤、代谢及遗传性疾病的治疗提供了崭新的思路和方法。目前,应用于实验
Basic procedures for bacteria culture
% agarose 1.05 g 1.5 g 3.0 g 20X TAE 7.5 ml 7.5 ml 7.5 ml ddH2O 142.5 ml 142.5 ml 142.5 ml EtBr (5 mg/ml) 25 ul 25
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