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Autoimmune regulator (AIRE)

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  • ¥1125 - 1875
  • HuaBio/华安生物
  • 2025年07月09日
  • WB, IHC-P, FC
  • Rabbit
  • Human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide within C-terminal human AIRE.

    • 亚型

      IgG

    • 形态

      Liquid

    • 克隆性

      Rabbit polyclonal Antibody

    • 标记物

      Non-conjugated

    • 适应物种

      Human

    • 库存

      现货

    • 供应商

      华安生物

    • 宿主

      Rabbit

    • 应用范围

      WB, IHC-P, FC

    • 浓度

      1 mg/mL.

    • 规格

      50ul/100ul

    规格:50ul产品价格:¥1125.0
    规格:100ul产品价格:¥1875.0
    The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).

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    图标文献和实验
    相关实验
    • Thymic Involution: Implications for Self-Tolerance

      . The unique expression of the AIRE (autoimmune regulator) gene in medullary thymic epithelial cells results in expression of a broad array of tissue-specific antigens. Thymocytes bearing T-cell receptors that bind to these tissuespecific antigens are clonally

    • Analysis of TGF-Inducible Apoptosis

      Transforming growth factor-β (TGF-β) is an important regulator of cellular growth and immune homeostasis (1 –3 ). TGFβ is a homodimeric 25-kDa protein which activates cellular signaling through the recruitment and transphos-phorylation

    • CD80分子

      ) Co-regulator of T cell activation with CD86 Has critical role in autoimmune, humoral, and transplant responses Positive staining (normal): activated B cells, T cells, macrophages, dendritic cells Reference: 112203  

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