Promegestone普美孕酮,34184-77-5

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Promegestone

CAS No. : 34184-77-5

MCE 国际站：Promegestone

产品活性：Promegestone (R-5020) 是一种孕激素，是一种有效的孕酮受体 (PR) 激动剂。Promegestone 具有内分泌调节和癌症研究的潜力。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Progesterone Receptor

In Vitro: Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC₅₀ of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC₅₀=1.93 nM).
Promegestone is inactive in HELN cells that express luciferase but no functional receptor.
Promegestone (10 nM) robustly stimulates SLC37A2 expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models.

In Vivo: Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth.

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