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- 2025年12月05日
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- 详细信息
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- 文献和实验
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 英文名：
Glucopyranosyl lipid A
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1246298-63-4
- 规格：
100 μg
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Monophosphoryl lipid A
CAS No. : 1246298-63-4
MCE 国际站：Monophosphoryl lipid A
产品活性：Monophosphoryl lipid A (Glucopyranosyl lipid A) 是一种 toll-like receptor 4 激动剂。Monophosphoryl lipid A 来源于非致病性沙门氏菌的细胞壁。Monophosphoryl lipid A 可用于免疫和疫苗研究。
作用靶点：Toll-like Receptor (TLR)
In Vitro: Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2.
?Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human.
?Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells.
In Vivo: The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice.
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文献和实验DNA Immunization in Combination with the Immunostimulant Monophosphoryl Lipid A
The use of the MPL� immunostimulant, a monophosphoryl lipid A preparation derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595, began with the studies of Johnson et al. (1 ). It was shown that LPS was a potent adjuvant
Characterizing Bile Acid and Lipid Metabolism in the Liver and Gastrointestinal Tract of Mice
system under both normal and pathological conditions. Methods are presented for characterizing liver and intestinal function with a focus on bile acid and lipid metabolism in the gut?liver axis. Curr. Protoc. Mouse Biol. 1:289?321 © 2011 by John Wiley & Sons
Preclinical Development of AS04
focuses on the methods that were used during the preclinical evaluation of AS04. AS04 consists of the combination of aluminum salts and 3′ -O -deacylated monophosphoryl lipid A (MPL), a detoxified lipid A derivative with retained immunostimulatory capa
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