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- 保存条件:
负20℃
- 保质期:
3个月
- 英文名:
pExpress-1-NQO1
- 库存:
50
- 供应商:
LSM BIO
- 规格:
2ug
pExpress-1-NQO1
PVT35431 2ug
pExpress-1-NQO1 Description
Alias:NM_001034535.1;DIA4Replicator:pUC
Clone strain:DH5a
Culture conditions:37centigrade
Note:825bp
Host:Escherichia coli
Use:
Species:Bovine
Gene type:cDNA
Prokaryotic resistance:Amp
Eukaryotic resistance:
Fluorescent protein:
Caution:
1. This product is FOR RESEARCH USE ONLY!
2. The item is lyophilized form, Please take the powder plasmid by centrifugation at 5000rpm/min for 1min. Add 20ul ddH2O in to the tube of plasmid.
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文献和实验绝处逢生,靳令经/李华/叶克强等开发双靶点抑制剂,间接靶向EGFR来治疗胶质母细胞瘤
新型替代靶向药刻不容缓! 个体化治疗其中一个重要策略是充分利用致癌突变引起的下游反应激活。大量证据表明 EGFRVIII 的激活与细胞内氧化应激水平相关。而 NQO1 和 GSTP1 是重要的 II 相解毒酶,可以减少醌类直接转换成氢醌,并消除氧化还原反应产生的活性氧。因此 NQO1 和 GSTP1 是潜在的治疗靶点。2020 年 10 月 21 日,埃默里大学医学院叶克强教授、华中科技大学药学院李华教授和同济大学医学院靳令经教授共同在 Journal of Hematology & Oncology
Bioreductive Prodrugs for Cancer Therapy
. This is particularly common in the case of the two-electron reductase NQO1 or DT-diaphorase. In this case, bioreductive drug activation may be independent of tumor oxygenation status.
Genome-Wide Overexpression Screen for Activators of Antioxidant Gene Transcription
that leads to transcriptional activation of the antioxidant response element (ARE). The ARE is located in the 59-flanking regions of many phase II detoxification and antioxidant enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and regulates
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