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- 技术资料
- 保质期：
4℃ for 2 years
- 库存：
大量
- CAS号：
1004316-88-4
- 英文名：
Cobicistat
- 保存条件：
4℃ for 2 years
- 供应商：
sun-shinechem, 上海永璨
- 规格：
100mg
CAS#1004316-88-4,
purity>98.5%,
Cobicistat is a licenced drug for use in the treatment of infection with the human immunodeficiency virus (HIV). cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir, higher concentrations of elvitgravir are achieved in the body with lower dosing, theoretically enhancing elvitgravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only currently approved booster, cobicistat has no anti-HIV activity of its own. Cobicistat is a component of the four-drug, fixed-dose combination HIV treatment elvitegravir/cobicistat/emtricitabine/tenofovir (known as the "Quad Pill").The Quad Pill was approved by the FDA in August 2012 for use in the United States and is owned by Gilead Sciences.
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文献和实验Clonality - X Chromosome Inactivation Assay
can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant lesion in females. The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome
Human Pregnane X Receptor (hPXR) Activation Assay in Stable Cell Lines
Analysis of pregnane X receptor (PXR, NR1I2) activation to determine induction of drug metabolizing enzymes and transporters and predict drug-drug interactions (DDIs) is a wildly used technique among in vitro assays. Direct assessment of PXR
Clonality - X Chromosome Inactivation Assay
Clonality - X Chromosome Inactivation Assay This method was successful in our lab using prostate tissue and for our specific objectives. Investigators must be aware that they will need to tailor the following protocol for their own research
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