| 背景： | Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue). BB2is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1BB1is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified. All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2is coupled to a Gq/11protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+mobilization, and cell growth.2 GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes.2In the brain, BB2has been implicated in regulating feeding behavior, thermoregulation, and memory formation.3 Finally, BB2is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2is considered a potential target for the development of both diagnostics and anti-cancer therapies.4 Alomone labs is pleased to offer a highly specific antibody directed against an epitope located in the 3rdextracellular loop of the human BB2receptor. Anti-Bombesin Receptor 2 (extracellular) antibody (#AG1369) can be used in western blot analysis, as well as immunocytochemical and immunohistochemical applications, and will recognize BB2from human, rat, mouse, and dog samples.REFERENCESReferences 1. Battey, J.F.et al.(1991)Proc Natl Acad Sci USA88, 395. 2. Kroog, G.S.et al.(1995)Med. Res. Rev.15, 389. 3. Ohki-Hamazaki, H.et al.(2005)Int. J. Dev. Biol.49, 293. 4. Reubi, J.C. (2003)Endocr. Rev.24, 389. |
