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cavgamma5 抗体
- 参考价格： ¥3025.0 - 5225.0
- 品 牌： abgent
- 货 号： AG1442
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫细胞化学
- 抗体类型： 一抗
- 主要序列号： Q8VHW8
- 同 源 性： Mouse, human - identical.
产品概览
| 背景： | Voltage-gated Ca2+(CaV) channels are ubiquitously expressed and function as Ca2+conducting pores in the plasma membrane1. On the basis of their voltage activation properties, the voltage-gated Ca2+channels can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels.2. CaVchannels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+flow across the membrane, and the auxiliary subunits α2δ, γ, and β3. CaVγ subunits inhibit CaVchannel activity and modulate its activation and inactivation kinetics. CaVγ subunits have little effect on CaVchannel trafficking4. The γ subunit is an integral membrane protein. The γ subunit family consists of at least 8 members, which share a number of common structural features. Each member is predicted to possess four transmembrane domains, with intracellular N- and C-termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues5. The CaVγ5 subunit is highly expressed in the liver, kidney, heart, lung, skeletal muscles, and, with a lower abundance, in testes5. The close association of epilepsy and ataxia with mutations in other neuronal voltage-dependent Ca2+channels suggests these are potential candidate phenotypes for defects in the CaVγ5 (CACNG5) gene6.REFERENCESReferences 1. Catterall, W.A. (2000)Annu. Rev. Cell. Dev. Biol. 16, 521. 2. Qin, N.et al.(2002)Mol. Pharmacol. 62, 485. 3. De Jongh, K.S.et al.(1990) J. Biol. Chem.265, 14738. 4. Arikkath, J.et al.(2003)Curr. Opin. Neurobiol.13, 298. 5. Lacinova, L.et al. (2005)Gen. Physiol. Biophys. 1, 1. 6. Klugbauer N.et al. (2000)FEBS Lett. 470,189. 7. Burgess, D.L.et al.(2009)Genome Res. 9, 1204. |
| 其他名字： | Voltage-dependent calcium channel γ-5 subunit, Neuronal Voltage-Gated Calcium Channel γ-5 Subunit, Transmembrane AMPAR Regulatory Protein γ-5 |
靶点信息
| 基因id： | 140726 |
应用与保存
| 配制： | 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size. |
| 配制前保存条件： | Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. |
| 配制前对照抗原保存条件： | Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. |
| 配制后保存条件： | The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min). |
| 配制后对照抗原保存条件： | -20ºC. |
| 配制后抗体浓度： | 0.8 mg/ml. |
| 稀释浓度： | WB~~1:1000ICC~~1:25 |
其他
| 参考文献： | References 1. Catterall, W.A. (2000)Annu. Rev. Cell. Dev. Biol. 16, 521. 2. Qin, N.et al.(2002)Mol. Pharmacol. 62, 485. 3. De Jongh, K.S.et al.(1990) J. Biol. Chem.265, 14738. 4. Arikkath, J.et al.(2003)Curr. Opin. Neurobiol.13, 298. 5. Lacinova, L.et al. (2005)Gen. Physiol. Biophys. 1, 1. 6. Klugbauer N.et al. (2000)FEBS Lett. 470,189. 7. Burgess, D.L.et al.(2009)Genome Res. 9, 1204. |
| 对照实验相关产品： | Control peptide antigen (supplied with the antibody free of charge). |
| 对照抗原配制： | 100 µl DDW. |
| 标记物： | Affinity purified antibody, lyophilized powder |
| 分子量： | 30924 Da |
| 提取： | Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| 预吸附控制： | 1 µg peptide per 1 µg antibody. |
| 验证肽： | Confirmed by mass-spectrography and amino acid analysis. |
| 规格： | 0.2 ml | 价格： | ¥5225.00 |
| 规格： | 25 µl | 价格： | ¥3025.00 |
| 规格： | 50 µl | 价格： | ¥4125.00 |
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