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connexin-26抗体
- 参考价格： ¥4125.0 - 5225.0
- 品 牌： abgent
- 货 号： AG1317
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫细胞化学
- 抗体类型： 一抗
- 其他名字： CX26, GJB2
- 对照抗原配制： 100 µl water.
产品概览
| 背景： | Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels1,2. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications1.Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells3. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response2,4,5.Due to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases and developmental abnormalities2,5,6. Mutations in the gene encoding for Connexin-26 protein are associated with deafness7.Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat Connexin-26. Anti-Connexin-26 antibody (#AG1317) can be used in western blot analysis and immunocytochemistry applications and was designed to recognize Connexin-26 from human, rat and mouse samples.REFERENCESReferences 1. Goodenough, D.A. and Paul, D.L. (2011)Cold Spring Harb. Persp. Biol.2009, 1. 2. Nakagawa, S.et al.(2010)Curr. Opin. Struct. Biol.20, 423. 3. Chew, S.S.L.et al.(2010)Exp. Neurol.225, 250. 4. Trexter, E.B.et al.(1996)Proc. Natl. Acad. Sci. U.S.A.93, 5836. 5. Hu, X.et al.(2006)Biophys. J.90, 140. 6. Tang, Q.et al.(2009)J. Gen. Physiol.133, 555. 7. Martin, P.E. et al. (1999) Hum. Mol. Genet. 8, 2369. |
靶点信息
| 基因id： | 394266 |
应用与保存
| 配制： | 50 µl or 0.2 ml deionized water, depending on the sample size. |
| 配制前保存条件： | Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. |
| 配制前对照抗原保存条件： | Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. |
| 配制后保存条件： | The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min). |
| 配制后对照抗原保存条件： | -20ºC. |
| 配制后抗体浓度： | 0.8 mg/ml. |
| 配制后缓冲液： | Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| 稀释浓度： | WB~~1:200ICC~~1:400 |
其他
| 参考文献： | References 1. Goodenough, D.A. and Paul, D.L. (2011)Cold Spring Harb. Persp. Biol.2009, 1. 2. Nakagawa, S.et al.(2010)Curr. Opin. Struct. Biol.20, 423. 3. Chew, S.S.L.et al.(2010)Exp. Neurol.225, 250. 4. Trexter, E.B.et al.(1996)Proc. Natl. Acad. Sci. U.S.A.93, 5836. 5. Hu, X.et al.(2006)Biophys. J.90, 140. 6. Tang, Q.et al.(2009)J. Gen. Physiol.133, 555. 7. Martin, P.E. et al. (1999) Hum. Mol. Genet. 8, 2369. |
| 对照实验相关产品： | Control peptide antigen (supplied with the antibody free of charge). |
| 标记物： | Affinity purified antibody, lyophilized powder |
| 主要序列号： | P21994 |
| 分子量： | 26451 Da |
| 同源性： | Mouse - identical; human - 12/13 amino acid residues identical. |
| 预吸附控制： | 1 µg peptide per 1 µg antibody. |
| 验证肽： | Confirmed by mass-spectrography and amino acid analysis. |
| 规格： | 0.2 ml | 价格： | ¥5225.00 |
| 规格： | 50 µl | 价格： | ¥4125.00 |
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