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creb单克隆抗体
- 参考价格： ¥3575.0
- 品 牌： abgent
- 货 号： AJ1199b
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫组化,免疫印迹,免疫荧光
- 克 隆 性： 单克隆
- 修 饰： pS133
- 抗体类型： 一抗
产品概览
| 背景： | CREB is a transcription factor protein that binds the cAMP response element (CRE), thereby stimulating transcription of this sequence. CREB plays a role in propagating numerous extracellular signals to the nuclues (1-3). CREB is activated by phosphorylation at the Ser133 position by various signaling pathways, and some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2 (1-3).REFERENCES1. Sheng, M., et al. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252: 14272. Xing, J., et al. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273: 9593. Xing, J., et al. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell Biol. 18: 1946 |
| 其他名字： | CREB1, Cyclic AMP-responsive element-binding protein 1 |
| 克隆名： | E113 |
靶点信息
| 基因id： | 1385 |
| 蛋白名： | CREB1 |
| 胞内定位： | Nucleus. |
应用与保存
| 稀释浓度： | IHC~~1:250WB~~1:500~2000 |
| 注意事项： | Creb Antibody Phospho (pS133) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Sheng, M., et al. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252: 14272. Xing, J., et al. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273: 9593. Xing, J., et al. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell Biol. 18: 1946 |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | P16220 |
| 分子量： | 36688 Da |
| 功能： | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| 规格： | 100µl | 价格： | ¥3575.00 |
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