| 参考文献： | Nicolas, E., et al. Eur. J. Hum. Genet. 18(10):1107-1113(2010)Willer, C.J., et al. Nat. Genet. 41(1):25-34(2009)Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| 主要序列号： | Q7Z2Z2 |
| 其他序列号： | Q8C0D5,NP_078856.4,NP_001035700.1 |
| 分子量： | 125430 Da |
| 功能： | Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. |
