| 基因别名： | KIAA0072,MGC23145,S5B |
| 基因名： | PSMD5 |
| 基因描述： | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 |
| 基因概览： | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base. [provided by RefSeq |
| 别名： | 26S protease subunit S5 basic,26S proteasome non-ATPase regulatory subunit 5,26S proteasome subunit S5B,OTTHUMP00000021990,proteasome 26S non-ATPase subunit 5 |
