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elongin a多克隆抗体

  • 参考价格： ¥1100.0 - 2310.0
  • 品  牌：  abgent
  • 货  号：  AP1918a
  • 适应物种：  人,小鼠
  • 应用范围：  免疫印迹
  • 克 隆 性：  多克隆
  • 亚  型：  Rabbit Ig
  • 抗体类型：  一抗
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  • 详细信息
  • 图片

详细信息

产品概览

背景： Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.REFERENCESBeausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Tamura, K., et al., Biochem. Biophys. Res. Commun. 309(1):189-195 (2003).Kile, B.T., et al., Trends Biochem. Sci. 27(5):235-241 (2002).Yamazaki, K., et al., J. Biol. Chem. 277(29):26444-26451 (2002).Kamura, T., et al., J. Biol. Chem. 276(32):29748-29753 (2001).
其他名字： TCEB3; Transcription elongation factor B polypeptide 3; Elongin 110 kDa subunit; Elongin-A; RNA polymerase II transcription factor SIII subunit A1; SIII p110

靶点信息

基因id： 6924
蛋白名： TCEB3
胞内定位： Nucleus (Probable).

应用与保存

稀释浓度： WB~~1:1000WB~~1:1000
注意事项： Elongin A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

其他

参考文献： Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Tamura, K., et al., Biochem. Biophys. Res. Commun. 309(1):189-195 (2003).Kile, B.T., et al., Trends Biochem. Sci. 27(5):235-241 (2002).Yamazaki, K., et al., J. Biol. Chem. 277(29):26444-26451 (2002).Kamura, T., et al., J. Biol. Chem. 276(32):29748-29753 (2001).
保存条件： Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
标记物： Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
主要序列号： Q14241
分子量： 89909 Da
功能： SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
规格： 80 µl (8 western blots) 价格： ¥1100.00
规格： 400 µl (40 western blots) 价格： ¥2310.00

  • Elongin A Antibody (Cat. #AP1918a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Elongin A antibody detected the Elongin A protein (arrow).

  • Western blot analysis of Elongin A (arrow) using rabbit polyclonal Elongin A Antibody (Cat. #AP1918a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Elongin A gene.

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