- 移动端
pak2单克隆抗体
- 参考价格： ¥3850.0
- 品 牌： abgent
- 货 号： AO1286a
- 适应物种： 人,猴
- 应用范围： 免疫印迹,免疫组化,免疫荧光
- 克 隆 性： 单克隆
- 亚 型： Mouse IgG1
- 抗体类型： 一抗
产品概览
| 背景： | PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.REFERENCES1. J Immunol. 2004 Jun 15;172(12):7324-34.2. J Mol Biol. 2007 Jul 20;370(4):620-32. |
| 其他名字： | PAK65; PAKgamma |
| 克隆名： | 3B5 |
靶点信息
| 基因id： | 5062 |
| 蛋白名： | PAK2 |
| 胞内定位： | Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane |
应用与保存
| 稀释浓度： | WB~~1:500~2000.IHC~~1:200~1000.IF~~1:200~1000. |
| 注意事项： | PAK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. J Immunol. 2004 Jun 15;172(12):7324-34.2. J Mol Biol. 2007 Jul 20;370(4):620-32. |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified recombinant fragment of PAK2 expressed in E. Coli. |
| 主要序列号： | Q13177 |
| 其他序列号： | NP_002568.2 |
| 分子量： | 58043 Da |
| 功能： | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase- activated PAK2 phosphorylates MKNK1 and reduces cellular translation. |
| 规格： | 0.1ml | 价格： | ¥3850.00 |
- 相关信息
| 产品名 | 品牌名 |
|---|---|
| msh2单克隆抗体 | abgent |
| mlh1单克隆抗体 | abgent |
| mapk1单克隆抗体 | abgent |
| btk单克隆抗体 | abgent |
| fgfr2多克隆抗体 | abgent |