ERIS分子的正确定位与其抗病毒密切相关

丁香通从北京大学生命科学学院了解到，该学院蒋争凡研究员课题组的论文 “ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization” 已被美国科学院院刊（PNAS）接受，蒋争凡研究员课题组克隆并证明了一个全新基因ERIS在抗病毒中起重要作用。

ERIS蛋白是蒋争凡课题组根据其功能与定位命名的新蛋白，该蛋白的上调可强烈激活细胞内抗病毒通路并诱导产生大量的I型干扰素；ERIS定位于内质网，正确定位对其行使抗病毒的生理功能至关重要；ERIS分子中2个内质网滞留序列对其定位及维持蛋白稳定性必需；ERIS在细胞感染后发生包括泛素化、磷酸化、寡聚化的多种修饰作用；Coumermycin诱导的ERIS二聚体化可激活ERIS介导的下游信号转导通路。

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蒋争凡研究员简介

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蒋争凡教授简介

任职

2006-至今：北京大学生命科学学院，研究员
1997-1999：北京大学生命科学学院，讲师

教育 

2003-2006：美国Scripps研究所（The Scripps Research Institute， La Jolla， San Diego， CA） 免疫学系 博士后
1999-2003：美国克利夫兰临床医学中心（Cleveland Clinic Foundation， Cleveland， OH） 免疫学系 博士后
1994-1997 北京大学 细胞分子生物学 哲学博士
1991-1994 兰州大学 生物学 理学硕士
1987-1991 兰州大学 生物学 理学学士

荣誉 

教育部“新世纪优秀人才”  2007
教育部科技一等奖  2006
美国癌症基金会博士后奖学金selected by Cancer Research Institute of the USA 2005-2006
国际细胞因子学会优秀博士后论文一等奖selected by the International Cytokine Society （ICS）  2002
国际干扰素及细胞因子学会博士后论文奖）selected by the International Society for Interferon and Cytokine Research，  2002
国家自然科学二等奖  2001
教育部科技一等奖 2000

杂志审稿

Nature， Science， Cell， Nature Immunology， Molecular Cell， Molecular and Cellular Biology， Journal of Biological chemistry， Proceedings of the National Academy of Sciences

论文目录

原始研究论文

1. Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S,Wilson I A, Olson A, Beutler B. 2006, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci USA. 103(29): 10961-66. (影响因子IF: 10.231)

2. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. 2005, CD14 is required for MyD88-independent LPS signaling. Nat Immunol. 6(6): 565-70. (影响因子IF: 28.18)

3. Jiang Z, Mak TW, Sen G, Li X. 2004, Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci USA. 101(10): 3533-8. (影响因子IF: 10.231)

4. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. 2003 Poly (I-C)-induced TLR3-mediated activation of NFkappa B and MAP kinase is through an IRAK-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem. 278(19): 16713-9. (影响因子IF: 5.854)

5. Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X. 2003, Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex. J Biol Chem. 278(13): 10952-6. (影响因子IF: 5.854)

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6. Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. 2002, Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 22(20): 7158-67. (影响因子IF: 8.1)

7. Qian Y, Zhao Z, Jiang Z, Li X. 2002, Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci USA. 99(14): 9386-91.(影响因子IF: 10.23)

8. Li X, Commane M, Jiang Z, Stark GR. 2001, IL-1-induced NFk B and JNK activation diverge at IRAK. Proc Natl Acad Sci USA. 98(8): 4461-5. (影响因子IF: 10.231)

9. Jiang Z, Hong X, Long H, Zhai ZH, 2000, Ceramides induce apoptosis in Hela cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. Cell Mol Life Sci. 57(7): 1117-25.(影响因子IF: 4.58)

10. M. Otsuka, Q. Jing, P. Georgel, New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S. C. Das, A. K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. 2007, Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27: 123-134.(影响因子IF:15.156)

11. Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X. 2007, Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification. J Biol Chem. 282(9):6075-89. (影响因子IF: 5.854)

12. Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B. 2004, Identification of a human NFkB-activating protein, TAB3. Proc Natl Acad Sci USA. 101(7): 2028-33. (影响因子IF: 10.231)

13. Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, Hoebe K, Bahram S, Oldstone MB, Beutler B. 2007, Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2): 304-313(影响因子IF: 3.08)

14. Huber M, Kalis C, Keck S, Jiang Z, Georgel P, et al. 2006 R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 36: 701-11. (影响因子IF: 4.876)

15. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. 2005, A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun. 73: 4512-21. (IF: 3.933)

16. Zhou Z, Hoebe K, Du X, Jiang Z, Shamel L, Beutler B. 2005, Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation. Eur J Immunol. 35 (6): 1918-27. (影响因子IF: 4.876)

17. Qin J, Jiang Z, Qian Y, Casanova JL, Li X. 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem. 279(25): 26748-53. (IF: 5.854)

18. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. 2004, Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. J Biol Chem. 279(36): 37670-6. (影响因子IF: 5.854)

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19. Nguyen H, Chatterjee-Kishore M, Jiang Z, Qing Y, Ramana CV, Bayes J, Commane M, Li X, Stark GR. 2003, IRAK-dependent phosphorylation of Stat1 on serine 727 in response to IL-1 and effects on gene expression. J Interferon Cytokine Res. 23 (4): 183-92. (影响因子IF: 2.09)

20. Jiang Z, Zhao Y, Hong X, Zhai ZH, 2000, Nuclear apoptosis induced by isolated mitochondria. Cell Res. 10(3): 221-32.(影响因子IF: 2.161)

21. Jiang Z, Zhu S, Sun YL, Zhai ZH, 1999, Induction of apoptosis in purified animal and plant nuclei by Xenopus egg extracts. Cell Res. 9(2): 79-90.(IF: 2.161)

22. Zhao Y, Jiang Z, Sun Y, Zhai ZH, 1999, Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells. FEBS Lett. 448(1): 197-200. (影响因子IF: 3.415)

23. Jiang Z, Zhang B, Zhai ZH. 1998, Nuclear assembly in vitro is independent of nucleosome/ chromatin assembly. Science in China (Series C), 28(3): 211-218. (IF: 0.482)

24. Jiang Z, Zhu S, Zhai ZH, 1998, Apoptosis in mouse liver nuclei induced in Xenopus egg extracts. Chinese Science Bulletin, 43(4): 409-412.(IF: 0.783)

25. Zhu S, Jiang Z, Zhang B, Lu Z, Zhai ZH, 1998, Identification of a DNase activated in Xenopus egg extracts undergoing apoptosis. Chinese Science Bulletin, 43 (4): 413-417. (IF: 0.783)

26. Ci YX, Zhang CY, Feng J, Lang AD, Huang CH, Jiang ZF, 1999, A photoelectric method for analyzing cell-free apoptosis induced by dATP. Analytical Communications 36: 143-5. (IF: 0.641)

综述

1. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X and Hoebe K, 2006, Genetic Analysis of Host Resistance: Toll-like Receptor Signaling and Immunity at Large. Annual Review of Immunology 24: 353-89. (影响因子IF: 47.4)

2. Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K, Beutler B. 2006, Genetic analysis of innate immunity. Adv Immunol. 91: 175-226. IF: 5.0)

3. Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K. 2005, Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 4:203-13. Review.

4. Hoebe K. Jiang Z, George P, Tabeta K, Janssen E, Du X, and Beutler B. 2006, TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. Current Pharmaceutical Design 12: 4123-34. (影响因子IF: 4.83)