• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        In Silico De-Immunization

        互联网

        889
        This protocol shows how to reduce immunogenicity by removing CD4+ T cell epitopes. These epitopes may limit the efficacy of protein therapeutics by inducing the development of a long-lived humoral immune response. The approach presented here mainly consists in (i) locate the T cell epitopes by in silico prediction, (ii) design point mutations to eliminate these T cell epitopes, (iii) test the lower immunogenicity of these mutated peptides and (iv) assess the preservation of the three dimensional structure of the antibody as well as its binding affinity for its target.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序