CarbonCarbon Bond-Forming Enzymes for the Synthesis of Non-natural Amino Acids
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An enzymatic methodology for the preparation of β-hydroxy-α-amino acid derivatives is described. The method consists of the stereoselective aldol addition reaction of glycine to N -Cbz-amino aldehydes furnishing 3-hydroxy-2,4-diaminobutyric derivatives.
![(3S)-3-[[(2S,11S)-11-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-12-oxo-1-azatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-2-carbonyl]amino]-4-oxo-4-(5-phenyl-1,3,4-oxadiazol-2-yl)butanoic acid，Moligand™，阿拉丁](https://img1.dxycdn.com/p/s14/2024/0619/722/0483842343985733081.jpg!wh200)
