CarbonCarbon Bond-Forming Enzymes for the Synthesis of Non-natural Amino Acids

互联网2014-02-13

702

An enzymatic methodology for the preparation of β-hydroxy-α-amino acid derivatives is described. The method consists of the stereoselective aldol addition reaction of glycine to N -Cbz-amino aldehydes furnishing 3-hydroxy-2,4-diaminobutyric derivatives.

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