2-O,4-C-Methyleneoxymethylene Bridged Nucleic Acids (2,4-BNACOC)
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The synthesis of 2′-O ,4′-C -methyleneoxymethylene bridged nucleoside (2′,4′-BNACOC ) phosphoramidites and oligonucleotides containing 2′,4′-BNACOC are described. 2′,4′-BNACOC phosphoramidites bearing natural nucleobases, such as thymine, cytosine, 5-methylcytosine, adenine, and guanine were synthesized. Moreover, fully or partially 2′,4′-BNACOC -modified oligonucleotides can be prepared by using a standard protocol except for a prolonged coupling time on an automated DNA synthesizer.
![N-(5-chloro-2-pyridyl)-N'-[(1R,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide，500572-10-1，阿拉丁](https://img1.dxycdn.com/p/s14/2024/0619/334/4435852687435733081.jpg!wh200)
