2-O,4-C-Methyleneoxymethylene Bridged Nucleic Acids (2,4-BNACOC)

互联网2014-02-13

2224

The synthesis of 2′-O ,4′-C -methyleneoxymethylene bridged nucleoside (2′,4′-BNA^COC ) phosphoramidites and oligonucleotides containing 2′,4′-BNA^COC are described. 2′,4′-BNA^COC phosphoramidites bearing natural nucleobases, such as thymine, cytosine, 5-methylcytosine, adenine, and guanine were synthesized. Moreover, fully or partially 2′,4′-BNA^COC -modified oligonucleotides can be prepared by using a standard protocol except for a prolonged coupling time on an automated DNA synthesizer.

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