Cloning Human Natural Killer Cells
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Our understanding of the phenotypical and functional heterogeneity of human natural killer (NK) cells has greatly advanced
over the past few years. This advancement has been greatly helped by the development of culture conditions for clonal proliferation
of NK cells. Analysis of human NK cell clones has led to the original observation that different NK cell clones recognize
distinct major histocompatibility complex (MHC) class I specificities. This has prompted the production of monoclonal antibodies
directed to NK cell surface antigens clonally distributed, and, ultimately, the biochemical and molecular definition of the
NK cell surface glycoproteins functioning as MHC class I receptors.