MALDI Imaging Technology Application in Neurosciences: From History to Perspectives
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Dynamic properties of the nervous system can now be investigated through mass spectrometry technologies. Generally, the application
of these powerful techniques requires the destruction of the specimen under study/examination, but recent technological advances
have made it possible to directly analyze tissue sections and perform 2-D or 3-D molecular ions mapping. We review from history
to perspective matrix-assisted laser desorption/ionization (MALDI) imaging technology and its application to the analysis
of molecular distributions of proteins and peptides in nervous tissues of both invertebrates and vertebrates, focusing in
particular on recent studies of neurodegenerative diseases, and early efforts to implement assays of neuronal development.
