Chiral Separations by Simulated Moving Bed Method Using Polysaccharide-Based Chiral Stationary Phases
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Generally, in using chromatography as an industrial-scale production process, batch separation is not adequate from the standpoint of productivity and mobile phase consumption; thus, a continuous separation is preferred. The simulated moving bed (SMB) method is one of the best popular practices of continuous chromatographic separation.
In this chapter, I would like to introduce actual practices of chiral SMB using polysaccharide-derived chiral stationary phases (CSPs), together with some laboratory-scale separation data.
![(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;848193-72-6;≥97% (chiral， HPLC);V10653-1mg](https://img1.dxycdn.com/p/s14/2025/1027/131/2990871289947862891.jpg!wh200)
