Models of Coronary Artery Occlusion and Reperfusion for the Discovery of Novel Antiischemic and Antiinflammatory Drugs for the Heart
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Cardiovascular disease (CVD) is the leading cause of death in the Western world. The American Heart Association estimates that the treatment of CVD in 1999 cost the U.S. more than $286 billion, and when unsuccessful, claimed the lives of more than 1 million U.S. citizens. Thus, in the U.S. every 29 s someone will suffer a coronary event, and every 60 s, someone will die from the consequences of acute myocardial infarction. Thus, there is still a great need to develop novel drugs for the therapy of CVD and particularly, acute myocardial infarction.
