Measurement of Macrophage-Mediated Cytolysis of Adenovirus-Infected Cells
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Macrophages are well-known for their ability to serve as phagocytes, ingesting and destroying microorganisms such as bacteria, and for their function in antigen presentation. Less appreciated, perhaps, is the fact that macrophages are also capable of recognizing and destroying certain abnormal self-cells; for example, some virus-infected and tumor cells are macrophage targets. This chapter describes an assay procedure by which the macrophagemediated cytolysis of such cells can be measured.
