• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Spontaneous and Experimental Metastasis Models: Nude Mice

        互联网

        887
        Immunodeficient mice are widely used for cancer research as they can provide an in vivo system in which to study the tumorigenicity and metastatic potential of human cancer cells. The athymic or “nude” mouse has been employed for a variety of experimental analyses of tumor growth, invasion, and metastasis. This chapter describes two types of experimental design for studying metastasis in vivo. The spontaneous metastasis models assess the ability of cells to disseminate from a local tumor, and are commonly initiated by the injection of the cells into an organ reflecting the tissue of origin of the cancer (orthotopic injection). Models of experimental metastasis evaluate the ability of tumor cells to arrest, extravasate, and grow in various organs following intravascular injection. The appropriate design of animal models using nude mice, and established human tumor cell lines, assists in the generation of novel information about the metastatic phenotype, and provides a valuable, preclinical system for testing anti-metastatic therapies.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序