Synthesis of Bioreducible Polycations with Controlled Topologies

Bioreducible polycations, which possess disulfide linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.